What Is Tesamorelin?
Tesamorelin is a synthetic 44-amino-acid analogue of human growth hormone-releasing hormone (GHRH). It features an N-terminal trans-3-hexenoic acid modification that resists enzymatic cleavage by dipeptidyl peptidase-4 (DPP-4), extending its plasma half-life to 26–38 minutes compared to native GHRH.
In clinical trials, Tesamorelin displays high specificity for pituitary GHRH receptors, reducing visceral adipose tissue (VAT) and improving lipodystrophy markers without suppressing endogenous pituitary production. Researchers routinely compare Tesamorelin against Sermorelin and CJC-1295 & Ipamorelin. Reconstituting Tesamorelin using our peptide calculator with bacteriostatic water guarantees exact milligram concentrations.
In clinical trials, Tesamorelin displays high specificity for pituitary GHRH receptors, reducing visceral adipose tissue (VAT) and improving lipodystrophy markers without suppressing endogenous pituitary production. Researchers routinely compare Tesamorelin against Sermorelin and CJC-1295 & Ipamorelin. Reconstituting Tesamorelin using our peptide calculator with bacteriostatic water guarantees exact milligram concentrations.
Tesamorelin Dosage Chart
Clinical research protocols for Tesamorelin frequently specify 1.0 mg or 2.0 mg daily doses. Choosing a 2.0 mL diluent volume for 10 mg vials creates a clean concentration of 5.0 mg/mL (20 units = 1.0 mg).
Vial: 2 mgWater: 1.0 mL
Concentration2.0 mg/mL
Target Dose1.0 mg (1,000 mcg)
Draw to Mark:50.0 Units
Vial: 5 mgWater: 2.0 mL
Concentration2.5 mg/mL
Target Dose1.0 mg (1,000 mcg)
Draw to Mark:40.0 Units
Vial: 10 mgWater: 2.0 mL
Concentration5.0 mg/mL
Target Dose1.0 mg (1,000 mcg)
Draw to Mark:20.0 Units
Vial: 10 mgWater: 2.0 mL
Concentration5.0 mg/mL
Target Dose2.0 mg (2,000 mcg)
Draw to Mark:40.0 Units
| Vial Size | Bac Water Added | Concentration | Target Research Dose | Draw Units (U-100) |
|---|---|---|---|---|
| 2 mg | 1.0 mL | 2.0 mg/mL | 1.0 mg (1,000 mcg) | 50.0 Units |
| 5 mg | 2.0 mL | 2.5 mg/mL | 1.0 mg (1,000 mcg) | 40.0 Units |
| 10 mg | 2.0 mL | 5.0 mg/mL | 1.0 mg (1,000 mcg) | 20.0 Units |
| 10 mg | 2.0 mL | 5.0 mg/mL | 2.0 mg (2,000 mcg) | 40.0 Units |
How to Reconstitute Tesamorelin
Reconstituting Tesamorelin requires careful fluid delivery down the vial glass wall to preserve its 44-amino-acid tertiary structure.
Visual Standard Operating Procedure
Tesamorelin Step-by-Step SOP
5 Standard Reconstitution Steps for Tesamorelin
- Disinfect rubber stoppers of both vials with 70% isopropyl alcohol prep pads.
- Draw 2.0 mL of sterile bacteriostatic water into a syringe.
- Inject water slowly against the inside glass wall of the Tesamorelin vial.
- Swirl gently between palms until the white lyophilized cake completely dissolves.
- Refrigerate reconstituted solution at 2°C–8°C.
❄️ Storage & Shelf-Life Notice (Tesamorelin)
Reconstituted Tesamorelin prepared with Bacteriostatic Water is stable for up to 28 days under refrigeration (2°C–8°C). Protect from light and heat.
⚠️ Common Preparation Mistakes to Avoid
Direct jet injection onto dry powder, shaking rapidly, and storing reconstituted vials at room temperature.
Tesamorelin Dosing FAQ
How much bac water do I add to 10mg Tesamorelin?↓
Adding 2.0 mL of bac water to a 10 mg Tesamorelin vial creates a concentration of 5.0 mg/mL. A 1.0 mg dose equals 20 units (0.20 mL) on a U-100 syringe.
How many units is 2 mg Tesamorelin on a 10mg vial with 2mL water?↓
With 2.0 mL of water in a 10 mg vial (5 mg/mL), a 2.0 mg dose is 40 units (0.40 mL).
What is the research half-life of Tesamorelin?↓
Tesamorelin has a terminal half-life of roughly 26 to 38 minutes in humans, extended by its trans-3-hexenoic acid modification.
Why is Tesamorelin studied for visceral fat loss?↓
Tesamorelin stimulates endogenous GH pulsatility, which activates lipolysis specifically in deep visceral adipose tissue depots.
Can Tesamorelin be frozen after reconstitution?↓
No. Liquid peptide solutions must never be frozen. Store refrigerated at 2°C–8°C.
Related Peptide Calculators & Stacks
CJC-1295 & Ipamorelin
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Sermorelin
Calculate Sermorelin GHRH analogue reconstitution, microgram dosing, and U-100 syringe units.
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