What Is Sermorelin?
Sermorelin acetate is a synthetic 29-amino-acid peptide analogue representing the N-terminal functional domain of endogenous human growth hormone-releasing hormone (GHRH 1-29 amide). Sermorelin binds to GHRH receptors on pituitary somatotroph cells, stimulating native synthesis and pulsatile release of somatotropin (growth hormone).
Because Sermorelin acts upstream through natural endocrine feedback loops, pituitary somatostatin release preserves normal physiological GH pulse control. In research settings, Sermorelin is evaluated alongside CJC-1295 & Ipamorelin and Tesamorelin. Sermorelin has an active half-life of 10 to 12 minutes. Calculating accurate dosing with our peptide calculator and bacteriostatic water ensures consistent microgram administration.
Because Sermorelin acts upstream through natural endocrine feedback loops, pituitary somatostatin release preserves normal physiological GH pulse control. In research settings, Sermorelin is evaluated alongside CJC-1295 & Ipamorelin and Tesamorelin. Sermorelin has an active half-life of 10 to 12 minutes. Calculating accurate dosing with our peptide calculator and bacteriostatic water ensures consistent microgram administration.
Sermorelin Dosage Chart
Sermorelin is typically dosed between 200 mcg and 500 mcg per night in clinical research trials. Reconstituting a 5 mg or 9 mg vial with 2.0 mL or 3.0 mL of bacteriostatic water delivers clean, low-volume syringe draws.
Vial: 2 mgWater: 2.0 mL
Concentration1,000 mcg/mL
Target Dose200 mcg
Draw to Mark:20.0 Units
Vial: 5 mgWater: 2.0 mL
Concentration2,500 mcg/mL
Target Dose300 mcg
Draw to Mark:12.0 Units
Vial: 5 mgWater: 2.5 mL
Concentration2,000 mcg/mL
Target Dose300 mcg
Draw to Mark:15.0 Units
Vial: 9 mgWater: 3.0 mL
Concentration3,000 mcg/mL
Target Dose300 mcg
Draw to Mark:10.0 Units
| Vial Size | Bac Water Added | Concentration | Target Research Dose | Draw Units (U-100) |
|---|---|---|---|---|
| 2 mg | 2.0 mL | 1,000 mcg/mL | 200 mcg | 20.0 Units |
| 5 mg | 2.0 mL | 2,500 mcg/mL | 300 mcg | 12.0 Units |
| 5 mg | 2.5 mL | 2,000 mcg/mL | 300 mcg | 15.0 Units |
| 9 mg | 3.0 mL | 3,000 mcg/mL | 300 mcg | 10.0 Units |
How to Reconstitute Sermorelin
Reconstituting Sermorelin requires standard aseptic diluent techniques to preserve fragile N-terminal peptide bonds.
Syringe Reading Diagram
U-100 Syringe Graduation & Measurement Line (Sermorelin)
5 Standard Reconstitution Steps for Sermorelin
- Sanitize both rubber stoppers with 70% isopropyl alcohol wipes.
- Draw 2.0 mL of sterile bacteriostatic water into a syringe.
- Inject water slowly down the side glass wall of the Sermorelin vial.
- Swirl gently until completely clear. Do not shake.
- Refrigerate reconstituted solution at 2°C–8°C.
❄️ Storage & Shelf-Life Notice (Sermorelin)
Reconstituted Sermorelin prepared with Bacteriostatic Water is stable for up to 30 days under refrigeration (2°C–8°C). Protect from light.
⚠️ Common Preparation Mistakes to Avoid
Vigorous shaking creating persistent foam, using unpreserved sterile water, and freezing reconstituted liquid solution.
Sermorelin Dosing FAQ
How much bac water do I add to 5mg Sermorelin?↓
Adding 2.0 mL of bac water to a 5 mg Sermorelin vial yields a concentration of 2,500 mcg/mL. A 300 mcg dose equals 12 units on a U-100 syringe.
How many units is 200 mcg Sermorelin on a 2mg vial?↓
With 2.0 mL of water in a 2 mg vial (1,000 mcg/mL), a 200 mcg dose equals 20 units (0.20 mL).
What is the half-life of Sermorelin?↓
Sermorelin has a circulating half-life of approximately 10–12 minutes, triggering rapid pituitary GH release.
How does Sermorelin compare to Tesamorelin?↓
Sermorelin is a 29-amino-acid GHRH fragment, whereas Tesamorelin is a 44-amino-acid GHRH analogue with a trans-3-hexenoic acid group designed for enhanced stability.
Can Sermorelin be taken with Ipamorelin?↓
Yes. Combining GHRH analogues like Sermorelin with GHRP agonists like Ipamorelin creates synergistic growth hormone release.