What Is AOD-9604?
AOD-9604 (Advanced Obesity Drug 9604) is a synthetic C-terminal peptide fragment of human growth hormone (hGH amino acids 177-191 with an added C-terminal tyrosine residue: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe). Designed to isolate the lipolytic (fat oxidation) action of hGH, AOD-9604 stimulates beta-3 adrenergic receptors on adipocytes without binding to GH receptors or elevating serum IGF-1 and blood glucose levels.
In preclinical models, AOD-9604 demonstrates lipolytic activity in visceral fat cells and inhibits lipogenesis (new fat formation). Researchers studying lipolytic pathways often compare AOD-9604 with Mots-c or GHRH secretagogues like Tesamorelin. AOD-9604 has a brief circulating half-life of approximately 30 minutes. Reconstituting AOD-9604 using our peptide calculator with bacteriostatic water ensures exact microgram unit calculations.
In preclinical models, AOD-9604 demonstrates lipolytic activity in visceral fat cells and inhibits lipogenesis (new fat formation). Researchers studying lipolytic pathways often compare AOD-9604 with Mots-c or GHRH secretagogues like Tesamorelin. AOD-9604 has a brief circulating half-life of approximately 30 minutes. Reconstituting AOD-9604 using our peptide calculator with bacteriostatic water ensures exact microgram unit calculations.
AOD-9604 Dosage Chart
AOD-9604 research protocols typically evaluate 300 mcg to 500 mcg daily micro-doses. Reconstituting a 5 mg vial with 2.0 mL of bacteriostatic water creates a concentration of 2,500 mcg/mL (12 units = 300 mcg).
Vial: 2 mgWater: 2.0 mL
Concentration1,000 mcg/mL
Target Dose300 mcg
Draw to Mark:30.0 Units
Vial: 5 mgWater: 2.0 mL
Concentration2,500 mcg/mL
Target Dose300 mcg
Draw to Mark:12.0 Units
Vial: 5 mgWater: 2.0 mL
Concentration2,500 mcg/mL
Target Dose500 mcg
Draw to Mark:20.0 Units
Vial: 10 mgWater: 2.0 mL
Concentration5,000 mcg/mL
Target Dose300 mcg
Draw to Mark:6.0 Units
| Vial Size | Bac Water Added | Concentration | Target Research Dose | Draw Units (U-100) |
|---|---|---|---|---|
| 2 mg | 2.0 mL | 1,000 mcg/mL | 300 mcg | 30.0 Units |
| 5 mg | 2.0 mL | 2,500 mcg/mL | 300 mcg | 12.0 Units |
| 5 mg | 2.0 mL | 2,500 mcg/mL | 500 mcg | 20.0 Units |
| 10 mg | 2.0 mL | 5,000 mcg/mL | 300 mcg | 6.0 Units |
How to Reconstitute AOD-9604
Reconstituting AOD-9604 requires gentle diluent introduction because C-terminal hGH fragments can precipitate if agitated prematurely.
Syringe Reading Diagram
U-100 Syringe Graduation & Measurement Line (AOD-9604)
5 Standard Reconstitution Steps for AOD-9604
- Sanitize stoppers of both vials with 70% isopropyl alcohol prep pads.
- Draw 2.0 mL of sterile bacteriostatic water into a syringe.
- Inject water slowly down the side glass wall of the AOD-9604 vial.
- Swirl gently until completely clear. Do not shake.
- Refrigerate reconstituted solution at 2°C–8°C.
❄️ Storage & Shelf-Life Notice (AOD-9604)
Reconstituted AOD-9604 prepared with Bacteriostatic Water is stable for up to 28 days under refrigeration (2°C–8°C). Protect from light.
⚠️ Common Preparation Mistakes to Avoid
Shaking the vial causing cloudiness or precipitation, using unpreserved sterile water, and freezing liquid reconstituted solutions.
AOD-9604 Dosing FAQ
How much bac water do I add to 5mg AOD-9604?↓
Adding 2.0 mL of bac water to a 5 mg AOD-9604 vial yields a concentration of 2,500 mcg/mL. A 300 mcg dose equals 12 units on a U-100 syringe.
Does AOD-9604 increase blood sugar or IGF-1?↓
No. AOD-9604 is a isolated lipolytic fragment that lacks the systemic domain responsible for IGF-1 induction and insulin resistance.
How many units is 500 mcg AOD-9604 on a 5mg vial with 2mL water?↓
With 2.0 mL of water in a 5 mg vial (2,500 mcg/mL), a 500 mcg dose equals 20 units (0.20 mL).
What is the half-life of AOD-9604?↓
AOD-9604 has a circulating half-life of roughly 30 minutes in blood plasma.
Can AOD-9604 be frozen after reconstitution?↓
No. Reconstituted liquid peptide solutions must never be frozen. Store refrigerated at 2°C–8°C.